Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30551030 | 0.85 | POLB (0.42) | NPC1POLBRAB9AMCL1GSK3B | |
| SCHEMBL31578459 | 0.85 | POLB (0.42) | NPC1POLBRAB9AMCL1GSK3B | |
| SCHEMBL25324303 | 0.85 | POLB (0.42) | NPC1POLBRAB9AMCL1GSK3B | |
| SCHEMBL25324308 | 0.85 | POLB (0.42) | NPC1POLBRAB9AMCL1GSK3B | |
| SCHEMBL25322039 | 0.84 | NPC1 (0.40) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL25326041 | 0.80 | GRM5 (0.38) | KDM4E | |
| SCHEMBL25320788 | 0.79 | CYP1A2 (0.34) | HPGDALDH1A1 | |
| SCHEMBL25320784 | 0.79 | CYP1A2 (0.34) | HPGDALDH1A1 | |
| SCHEMBL30886216 | 0.78 | MAPT (0.40) | NPC1POLBRAB9AHPGDMEN1 | |
| SCHEMBL30886268 | 0.77 | GSK3B (0.41) | POLBGSK3BMEN1KMT2AFASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |