Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24365825 | 0.84 | NPC1 (0.55) | NPC1RAB9APPARATP53MAPT | |
| SCHEMBL30470952 | 0.84 | NPC1 (0.55) | NPC1RAB9APPARATP53MAPT | |
| SCHEMBL25320553 | 0.73 | NPC1 (0.44) | NPC1RAB9ATP53MAPTPOLB | |
| SCHEMBL24365817 | 0.71 | NPC1 (0.54) | NPC1RAB9AGAATP53MAPT | |
| SCHEMBL30469538 | 0.71 | NPC1 (0.54) | NPC1RAB9AGAATP53MAPT | |
| Formaldehyde SCHEMBL25322403 | 0.71 | NPC1 (0.51) | NPC1RAB9AGAATP53MAPT | |
| SCHEMBL24233849 | 0.71 | UBE2M (0.39) | NPC1RAB9AGAAALDH1A1UBE2M | |
| SCHEMBL24365032 | 0.69 | NPC1 (0.60) | NPC1RAB9APPARAGAATP53 | |
| SCHEMBL30470110 | 0.69 | NPC1 (0.60) | NPC1RAB9APPARAGAATP53 | |
| SCHEMBL24365158 | 0.68 | NPC1 (0.60) | NPC1RAB9APPARATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469455-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |