SCHEMBL25323644

SCHEMBL25323644

COc1cccc2c1sc1nncn12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TNKS2 Q9H2K2 15/20 1.00
▸ PARP15 Q460N3 14/20 1.00
▸ PARP10 Q53GL7 13/20 1.00
▸ PARP2 Q9UGN5 14/20 0.66
▸ KDM4E B2RXH2 1/20 0.46
▸ BRPF1 P55201 1/20 0.43
▸ PARP14 Q460N5 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25325363 0.78 PARP2 (1.00) TNKS2PARP15PARP10PARP2KDM4E
SCHEMBL25323203 0.78 TNKS2 (1.00) TNKS2PARP15PARP10PARP2KDM4E
SCHEMBL11743573 0.76 TNKS2 (1.00) TNKS2PARP15PARP10PARP2BRPF1
SCHEMBL25326183 0.70 TNKS2 (1.00) TNKS2PARP15PARP10PARP2BRPF1
SCHEMBL11651246 0.70 PARP15 (0.54) TNKS2PARP15PARP10PARP2KDM4E
SCHEMBL11652662 0.70 PARP15 (0.54) TNKS2PARP15PARP10PARP2KDM4E
SCHEMBL11651046 0.69 PARP15 (0.52) TNKS2PARP15PARP10PARP2KDM4E
SCHEMBL31248569 0.68 TNKS2 (1.00) TNKS2PARP15PARP10PARP2BRPF1
SCHEMBL2489012 0.68 TNKS2 (1.00) TNKS2PARP15PARP10PARP2BRPF1
SCHEMBL11652666 0.68 PARP15 (0.51) TNKS2PARP15PARP10PARP2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250177359-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS OULUN YLIOPISTO (FI) 2025-06-05 — — US disclosed
EP-4469046-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS Oulun Yliopisto (FI) 2024-12-04 — — EP disclosed
WO-2023144450-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS OULUN YLIOPISTO (FI) 2023-08-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250177359-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS NAMPT, NADK, NQO1 TNKS2 29/4885PARP15 9/4885PARP10 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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