SCHEMBL25324344

SCHEMBL25324344

CC(C)(C)OC(=O)NC1CC(c2nc3cc(Br)ccc3s2)C1.NC1CC(c2nc3cc(Br)ccc3s2)C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 3/20 0.42
DYRK1A Q13627 2/20 0.40
ADORA1 P30542 1/20 0.37
LIPG Q9Y5X9 1/20 0.36
ACACB O00763 1/20 0.36
EPHX2 P34913 1/20 0.35
TUBB4A P04350 1/20 0.35
TUBB P07437 1/20 0.35
TUBA3C P0DPH7 1/20 0.35
TUBA1B P68363 1/20 0.35
TUBA4A P68366 1/20 0.35
TUBB4B P68371 1/20 0.35
TUBB3 Q13509 1/20 0.35
TUBB2A Q13885 1/20 0.35
TUBB8 Q3ZCM7 1/20 0.35
TUBA3E Q6PEY2 1/20 0.35
TUBA1A Q71U36 1/20 0.35
TUBA1C Q9BQE3 1/20 0.35
TUBB6 Q9BUF5 1/20 0.35
TUBB2B Q9BVA1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29477523 0.95 DYRK1A (0.44) PPARADYRK1AADORA1LIPGACACB
SCHEMBL25922451 0.95 DYRK1A (0.44) PPARADYRK1AADORA1LIPGACACB
SCHEMBL30470911 0.80 NPC1 (0.42) PPARADYRK1AADORA1ACACBTUBB4A
SCHEMBL25922452 0.80 NPC1 (0.42) PPARADYRK1AADORA1ACACBTUBB4A
SCHEMBL25955538 0.76 KCNK3 (0.42) PPARADYRK1AADORA1ACACBLMNA
SCHEMBL29477786 0.76 KCNK3 (0.42) PPARADYRK1AADORA1ACACBLMNA
SCHEMBL29081626 0.76 KCNK3 (0.42) PPARADYRK1AADORA1ACACBLMNA
SCHEMBL25334616 0.75 KCNK3 (0.43) PPARADYRK1AADORA1ACACBLMNA
SCHEMBL25324340 0.74 PPARA (0.37) PPARADYRK1AADORA1ACACBTUBB4A
SCHEMBL25922621 0.73 UBE2M (0.53) DYRK1AKMT2AMEN1LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469447-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 EP disclosed
EP-4469455-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 EP disclosed
WO-2023146990-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed
WO-2023146989-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed