Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324570 | 1.00 | HSD17B13 (0.36) | HSD17B13PRMT5IRAK4WDR77CRBN | |
| SCHEMBL30551581 | 0.96 | IRAK4 (0.34) | HSD17B13PRMT5IRAK4WDR77CRBN | |
| SCHEMBL30551335 | 0.96 | PRMT5 (0.36) | HSD17B13PRMT5IRAK4WDR77 | |
| SCHEMBL25319112 | 0.96 | PRMT5 (0.36) | HSD17B13PRMT5IRAK4WDR77 | |
| SCHEMBL25325010 | 0.96 | IRAK4 (0.34) | HSD17B13PRMT5IRAK4WDR77CRBN | |
| SCHEMBL25912351 | 0.94 | IRAK4 (0.41) | HSD17B13PRMT5IRAK4WDR77 | |
| SCHEMBL25322193 | 0.89 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL25920493 | 0.88 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL25324291 | 0.87 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL25324287 | 0.87 | PRMT5 (0.35) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163048-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2025-05-22 | — | — | US | disclosed |
| EP-4469455-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163048-A1 | COMPOUNDS AND METHODS OF USE | RB1, CYP1B1, REN | HSD17B13 589/4885PRMT5 562/4885IRAK4 4158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.