SCHEMBL25328146

SCHEMBL25328146

CC1CN(c2cc(=O)n(C)c3ccc(C#N)nc23)[C@@H](C)CN1C(c1ccc(F)cc1)c1cc(F)cc(F)c1

nearest known ligand 0.93

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGKZ Q13574 20/20 0.93
DGKA P23743 19/20 0.93

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21830901 1.00 DGKZ (0.93) DGKZDGKA
SCHEMBL30910598 1.00 DGKZ (0.93) DGKZDGKA
SCHEMBL21831277 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL21831135 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL30910514 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL25327542 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL21831090 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL21830979 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL30910464 0.97 DGKZ (1.00) DGKZDGKA
SCHEMBL30910588 0.97 DGKZ (1.00) DGKZDGKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3814348-B9 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-11-01 EP disclosed
EP-3814348-B1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-08-02 EP disclosed