SCHEMBL25328586

SCHEMBL25328586

Cc1ccc(S(=O)(=O)O)c(CC(C)(C)CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.32
ACSS2 Q9NR19 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21749305 0.78 LMNA (0.32)
SCHEMBL10644732 0.78 POLB (0.35) CYP2C9
SCHEMBL7627786 0.77 MEN1 (0.39)
SCHEMBL30667161 0.77 MEN1 (0.39)
SCHEMBL10648574 0.76 KMT2A (0.36)
SCHEMBL10645369 0.75 POLB (0.33) CYP2C9
SCHEMBL658696 0.74 GAA (0.39)
SCHEMBL4453794 0.74 ATM (0.32)
SCHEMBL10647911 0.73 POLB (0.37)
SCHEMBL20601810 0.72 CYP3A4 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3644991-B1 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME LLC (US) 2023-08-02 EP disclosed