Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MMP14 | P50281 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632667 | 0.84 | KDM4E (0.38) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL25329134 | 0.84 | MAPT (0.40) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL1634205 | 0.73 | KDM4E (0.50) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL4451993 | 0.71 | MAPT (0.55) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL1784639 | 0.71 | MAPT (0.68) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL30515553 | 0.71 | MAPT (0.34) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL1633632 | 0.71 | MAPT (0.34) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| SCHEMBL4448881 | 0.68 | MAPT (0.51) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| Chlorquinaldol SCHEMBL29641617 | 0.68 | MAPT (1.00) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 | |
| Chlorquinaldol SCHEMBL29607534 | 0.68 | MAPT (1.00) | MAPTALDH1A1MEN1HSP90AA1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023143135-A1 | QUINAZOLINE DERIVATIVE AND USE THEREOF | 赛诺哈勃药业（成都）有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-116514728-A | Quinazoline derivative and application thereof | 赛诺哈勃药业（成都）有限公司 | 2023-08-01 | — | — | CN | disclosed |