Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.55 |
| ▸ | MMP14 | P50281 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448881 | 0.81 | MAPT (0.51) | MAPTMEN1HTTKMT2ASMN1; SMN2 | |
| Bromide SCHEMBL4451997 | 0.79 | MAPT (0.50) | MAPTMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL28884188 | 0.74 | ALK (0.40) | TDP1LMNARECQLHIF1AL3MBTL1 | |
| SCHEMBL29888687 | 0.74 | ALK (0.40) | TDP1LMNARECQLHIF1AL3MBTL1 | |
| SCHEMBL16459993 | 0.71 | IDO1 (0.36) | KMT2ASMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL25328672 | 0.71 | MAPT (0.51) | MAPTMEN1HTTKMT2ASMN1; SMN2 | |
| Chloroxine SCHEMBL29389908 | 0.71 | KDM4E (1.00) | MAPTMEN1HTTKMT2ASMN1; SMN2 | |
| Chloroxine SCHEMBL29399997 | 0.71 | KDM4E (1.00) | MAPTMEN1HTTKMT2ASMN1; SMN2 | |
| Chloroxine SCHEMBL3350 | 0.71 | KDM4E (1.00) | MAPTMEN1HTTKMT2ASMN1; SMN2 | |
| Chloroxine SCHEMBL231205 | 0.69 | KDM4E (0.96) | MAPTMEN1HTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362339-B1 | ELECTROLUMINESCENCE | 3M INNOVATIVE PROPERTIES COMPANY | 2002-03-26 | — | — | US | claimed |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-9302993-B2 | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LIMITED (AU) | 2016-04-05 | — | — | US | disclosed |
| US-9302993-B2 | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LIMITED (AU) | 2016-04-05 | — | — | US | disclosed |
| US-9302993-B2 | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LIMITED (AU) | 2016-04-05 | — | — | US | disclosed |
| US-20150335635-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-11-26 | — | — | US | disclosed |
| US-20150335635-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-11-26 | — | — | US | disclosed |
| US-20150335635-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-11-26 | — | — | US | disclosed |
| US-9169211-B2 | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-10-27 | — | — | US | disclosed |
| EP-1539700-A4 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LTD (AU) | 2006-06-28 | — | — | EP | disclosed |
| US-20060089380-A1 | 8-Hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LTD. (AU) | 2006-04-27 | — | — | US | disclosed |
| EP-1539700-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | Prana Biotechnology Ltd (AU) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004007461-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004007461-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2004-01-22 | — | — | WO | disclosed |
| EP-1218345-B1 | METHOD OF MAKING METAL 8-QUINOLINOLATO COMPLEXES | 3M INNOVATIVE PROPERTIES CO (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1218345-A1 | METHOD OF MAKING METAL 8-QUINOLINOLATO COMPLEXES | 3M Innovative Properties Company (US) | 2002-07-03 | — | — | EP | disclosed |
| US-20020040143-A1 | Method of making metal 8-quinolinolato complexes | 3M INNOVATIVE PROPERTIES COMPANY | 2002-04-04 | — | — | US | disclosed |
| US-6362339-B1 | ELECTROLUMINESCENCE | 3M INNOVATIVE PROPERTIES COMPANY | 2002-03-26 | — | — | US | disclosed |
| WO-2001025211-A1 | METHOD OF MAKING METAL 8-QUINOLINOLATO COMPLEXES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2001-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150335635-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PARK7, COQ8A, NLN | MAPT 170/4885MEN1 1871/4885HTT 15/4885 |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | TERT, TERF2, RNGTT | MAPT 2505/4885MEN1 3550/4885HTT 178/4885 |
| US-20020040143-A1 | Method of making metal 8-quinolinolato complexes | COQ8A, SDHA, LDHA | MAPT 424/4885MEN1 523/4885HTT 856/4885 |
| US-20060089380-A1 | 8-Hydroxy quinoline derivatives | PARK7, HTT, SNCA | MAPT 122/4885MEN1 3123/4885HTT 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.