Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 3/20 | 0.63 |
| ▸ | CDK7 | P50613 | 2/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.53 |
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.53 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | CCNK | O75909 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25329276 | 1.00 | CDK9 (0.63) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL29040469 | 0.95 | CDK7 (0.62) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL23181216 | 0.95 | CDK7 (0.62) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL30978800 | 0.95 | CDK9 (0.68) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL29214366 | 0.95 | CDK9 (0.68) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL25327813 | 0.91 | PTK2 (0.56) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL25327808 | 0.91 | PTK2 (0.56) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL25328917 | 0.90 | PTK2 (0.57) | CDK9CDK7PTK2ALKROS1 | |
| SCHEMBL25329554 | 0.90 | PTK2 (0.57) | CDK9CDK7PTK2ZAP70ALK | |
| SCHEMBL25329544 | 0.90 | PTK2 (0.57) | CDK9CDK7PTK2ZAP70ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023143482-A1 | 2-AMINOPYRIMIDINE COMPOUND OR SALT, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海辉启生物医药科技有限公司 | 2023-08-03 | — | — | WO | disclosed |