Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | PI4KA | P42356 | 2/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.44 |
| ▸ | GMPS | P49915 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28169819 | 0.92 | ADORA2A (0.48) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL28143272 | 0.89 | ADORA2A (0.36) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30716566 | 0.86 | ADORA2A (0.53) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL29291819 | 0.85 | TAS1R3 (0.46) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL10605544 | 0.84 | ADORA2A (0.47) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL28237443 | 0.80 | HPGD (0.46) | ADORA3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27574696 | 0.79 | ADORA2A (0.42) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL28037447 | 0.79 | ADORA2A (0.54) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL27592100 | 0.79 | ADORA2A (0.48) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL27446941 | 0.78 | ADORA1 (0.45) | ADORA2API4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139269-A1 | MODULATION OF SUV39H1 EXPRESSION BY RNAS | MNEMO THERAPEUTICS (FR) | 2023-07-27 | — | — | WO | disclosed |
| CN-105814205-B | Complement component iRNA composition and its application method | 阿尔尼拉姆医药品有限公司 | 2019-11-19 | — | — | CN | disclosed |
| CN-110317810-A | TMPRSS6 IRNA composition and its application method | 阿尔尼拉姆医药品有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-110249053-A | COMBINATION THERAPY FOR C3 INHIBITION | 阿佩利斯制药有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-110249052-A | Synthetic guide molecules, compositions, and methods related thereto | 爱迪塔斯医药公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-110168084-A | System and method for single-shot guide RNA (ogRNA) targeting that is endogenous and carrying out source DNA | 爱迪塔斯医药公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-105452463-B | TMPRSS6 IRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109843915-A | Genetically engineered cell and preparation method thereof | 朱诺治疗学股份有限公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109219659-A | Agents for treating oculopharyngeal muscular dystrophy (OPMD) and uses thereof | 贝尼泰克生物制药有限公司 | 2019-01-15 | — | — | CN | disclosed |
| CN-108779462-A | Composition for treating hemoglobinopathy and method | 诺华股份有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108473526-A | Process for producing oligonucleotide and nucleoside, nucleotide or oligonucleotide | 味之素株式会社 | 2018-08-31 | — | — | CN | disclosed |
| CN-108348541-A | Methods and compositions for treating proprotein convertase subtilisin KEXIN (PCSK9) gene-related disorders | 阿尔尼拉姆医药品有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-108271386-A | factor XII (Hagemann factor) (F12), kallikrein B, plasma (Freund's Lehci factor) 1(K L KB1) and kininogen 1(KNG1) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2018-07-10 | — | — | CN | disclosed |
| CN-108220295-A | PCSK9 iRNA compositions and its application method | 阿尔尼拉姆医药品有限公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-108064294-A | Hepatitis B virus (HBV) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2018-05-22 | — | — | CN | disclosed |
| CN-108064154-A | Compositions and methods for inhibiting expression of the HAO1 (glycolate oxidase 1) gene | 阿尔尼拉姆医药品有限公司 | 2018-05-22 | — | — | CN | disclosed |
| CN-104854242-B | PCSK9 iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2018-03-16 | — | — | CN | disclosed |
| CN-107075516-A | Modified double-stranded RNA reagents | 阿尔尼拉姆医药品有限公司 | 2017-08-18 | — | — | CN | disclosed |