Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3100 | 0.90 | AGTR1 (0.46) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL2510 | 0.90 | AGTR1 (0.53) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL7271515 | 0.90 | AGTR1 (0.53) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL3042 | 0.89 | AGTR1 (0.54) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL3031 | 0.87 | AGTR1 (0.45) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL2789 | 0.86 | AGTR1 (0.55) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL2113 | 0.85 | AGTR1 (0.46) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL2118 | 0.83 | AGTR1 (0.55) | AGTR1LTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL2530 | 0.82 | AGTR1 (0.44) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL2673 | 0.81 | AGTR1 (0.58) | AGTR1LTB4R2HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |