Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 11/20 | 0.49 |
| ▸ | JUN | P05412 | 10/20 | 0.49 |
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25330388 | 1.00 | JAK1 (0.52) | JAK1MAPK8MAPK9JUNCDK2 | |
| SCHEMBL22895533 | 0.83 | USP30 (0.52) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL28552023 | 0.83 | USP30 (0.52) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL23292274 | 0.83 | USP30 (0.52) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL23292333 | 0.83 | CDK12 (0.56) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL22895770 | 0.83 | CDK12 (0.56) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL28544916 | 0.83 | CDK12 (0.56) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL22900783 | 0.82 | JAK1 (0.54) | JAK1MAPK8MAPK9CDK2MAPK10 | |
| SCHEMBL29926869 | 0.82 | JAK1 (0.54) | JAK1MAPK8MAPK9CDK2MAPK10 | |
| SCHEMBL23292466 | 0.82 | USP30 (0.50) | MAPK8MAPK9JUNCDK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023143482-A1 | 2-AMINOPYRIMIDINE COMPOUND OR SALT, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海辉启生物医药科技有限公司 | 2023-08-03 | — | — | WO | disclosed |