Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24071023 | 0.95 | NPC1 (0.61) | NPC1RAB9AGPR142P2RX1BRAF | |
| SCHEMBL30211942 | 0.83 | NPC1 (0.59) | NPC1RAB9AP2RX1BRAFMAPT | |
| SCHEMBL24070620 | 0.83 | NPC1 (0.59) | NPC1RAB9AP2RX1BRAFMAPT | |
| SCHEMBL25949228 | 0.81 | RXFP1 (0.67) | NPC1RAB9AALDH1A1HTTKCNK3 | |
| SCHEMBL2107071 | 0.81 | NPC1 (0.58) | NPC1RAB9AP2RX1BRAFMAPT | |
| SCHEMBL22025463 | 0.79 | NPC1 (0.63) | NPC1RAB9AGPR142P2RX1BRAF | |
| SCHEMBL22065214 | 0.78 | NPC1 (0.62) | NPC1RAB9AGPR142P2RX1BRAF | |
| SCHEMBL24070816 | 0.78 | MAPT (0.65) | RAB9AP2RX1MAPTHTTKCNK3 | |
| SCHEMBL30211957 | 0.78 | MAPT (0.65) | RAB9AP2RX1MAPTHTTKCNK3 | |
| SCHEMBL2105853 | 0.78 | NPC1 (0.67) | NPC1RAB9AP2RX1BRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227447-A1 | BENZYLAMINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227447-A1 | BENZYLAMINE DERIVATIVES AS DDRS INHIBITORS | DDR2, DDR1, DDRGK1 | NPC1 2973/4885RAB9A 2278/4885GPR142 2626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.