Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24086965 | 0.89 | ADORA2A (0.48) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL1355435 | 0.88 | ADORA2A (0.76) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL1355364 | 0.88 | ADORA2A (0.76) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL1355476 | 0.87 | ADORA2A (0.75) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL24087131 | 0.86 | ADORA2A (0.77) | ADORA2AMKNK1MKNK2IGF1RCNR2 | |
| SCHEMBL24086888 | 0.85 | ADORA2A (0.48) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL30814852 | 0.83 | ADORA2A (0.42) | ADORA2AMKNK1MKNK2CYP3A4CNR2 | |
| SCHEMBL12133219 | 0.81 | ADORA2A (0.68) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL30445752 | 0.78 | MKNK1 (0.46) | ADORA2AMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL25338708 | 0.78 | MKNK1 (0.46) | ADORA2AMKNK1MKNK2CYP3A4EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3870582-B1 | 5-AZAINDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2023-07-19 | — | — | EP | claimed |