Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30568453 | 1.00 | USP30 (0.35) | USP30AAK1NLRP3BACE1BACE2 | |
| SCHEMBL25343527 | 0.93 | USP30 (0.34) | USP30AAK1 | |
| SCHEMBL30568534 | 0.93 | USP30 (0.34) | USP30AAK1 | |
| SCHEMBL30568503 | 0.91 | USP30 (0.33) | USP30AAK1 | |
| SCHEMBL25343953 | 0.91 | USP30 (0.33) | USP30AAK1 | |
| SCHEMBL25343304 | 0.91 | USP30 (0.33) | USP30BACE1BACE2 | |
| SCHEMBL30568672 | 0.91 | USP30 (0.33) | USP30BACE1BACE2 | |
| SCHEMBL25343427 | 0.90 | USP30 (0.36) | USP30AAK1BACE1BACE2 | |
| SCHEMBL30568626 | 0.90 | USP30 (0.36) | USP30AAK1BACE1BACE2 | |
| SCHEMBL25346349 | 0.87 | USP30 (0.35) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |