Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25343427 | 1.00 | USP30 (0.36) | USP30TRPV4GBA1PDK2AAK1 | |
| SCHEMBL25346349 | 0.96 | USP30 (0.35) | USP30TRPV4GBA1PDK2 | |
| SCHEMBL30568483 | 0.96 | USP30 (0.35) | USP30TRPV4GBA1PDK2 | |
| SCHEMBL30568630 | 0.90 | USP30 (0.34) | USP30GBA1PDK2 | |
| SCHEMBL25341995 | 0.90 | USP30 (0.34) | USP30GBA1PDK2 | |
| SCHEMBL25344607 | 0.90 | USP30 (0.35) | USP30AAK1BACE1BACE2 | |
| SCHEMBL30568453 | 0.90 | USP30 (0.35) | USP30AAK1BACE1BACE2 | |
| SCHEMBL30568534 | 0.89 | USP30 (0.34) | USP30AAK1 | |
| SCHEMBL25343527 | 0.89 | USP30 (0.34) | USP30AAK1 | |
| SCHEMBL25343953 | 0.87 | USP30 (0.33) | USP30AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |