Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 4/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL929357 | 0.91 | CHRM2 (0.55) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL1979233 | 0.89 | NR1H2 (0.49) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL18702051 | 0.87 | CHRM2 (0.54) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL18711901 | 0.82 | CHRM2 (0.56) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL1711297 | 0.80 | HSD11B1 (0.39) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL30276651 | 0.79 | NR1H2 (0.55) | NR1H2USP2SMN1; SMN2RORCGPR119 | |
| SCHEMBL30276459 | 0.79 | NR1H2 (0.55) | NR1H2USP2SMN1; SMN2RORCGPR119 | |
| SCHEMBL18713026 | 0.78 | CHRM2 (0.59) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL25896209 | 0.78 | CHRM2 (0.59) | CHRM2CHRM1CHRM3NR1H2PREP | |
| SCHEMBL31309864 | 0.78 | CHRM2 (0.51) | CHRM2CHRM1CHRM3NR1H2PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |