Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27211093 | 1.00 | PRMT5 (0.46) | PRMT5PDE4BHPGDSSCN9AJAK2 | |
| SCHEMBL30473704 | 1.00 | PRMT5 (0.46) | PRMT5PDE4BHPGDSSCN9AJAK2 | |
| SCHEMBL30473696 | 0.90 | PRMT5 (0.44) | PRMT5PDE4BHPGDSSCN9AJAK2 | |
| SCHEMBL25343933 | 0.90 | PRMT5 (0.44) | PRMT5PDE4BHPGDSSCN9AJAK2 | |
| SCHEMBL27211233 | 0.90 | PRMT5 (0.44) | PRMT5PDE4BHPGDSSCN9AJAK2 | |
| SCHEMBL30473674 | 0.87 | PIK3CD (0.51) | PRMT5PDE4BHPGDSJAK2JAK1 | |
| SCHEMBL27211356 | 0.87 | PIK3CD (0.51) | PRMT5PDE4BHPGDSJAK2JAK1 | |
| SCHEMBL25344277 | 0.87 | PIK3CD (0.51) | PRMT5PDE4BHPGDSJAK2JAK1 | |
| SCHEMBL25342400 | 0.86 | PDE4B (0.47) | PRMT5PDE4BHPGDSSCN9AJAK2 | |
| SCHEMBL29457556 | 0.86 | PDE4B (0.47) | PRMT5PDE4BHPGDSJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225746-A1 | MRGX2 ANTAGONISTS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022073904-A1 | MRGX2 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |