Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534611 | 1.00 | HSD17B10 (0.55) | HSD17B10KMT2APDE7AMAPTMEN1 | |
| SCHEMBL10919031 | 0.85 | HSD17B10 (0.53) | HSD17B10KMT2APDE7AMAPTMEN1 | |
| SCHEMBL2595990 | 0.85 | MAPT (0.49) | HSD17B10KMT2AMAPTMAPK1LMNA | |
| SCHEMBL1906515 | 0.81 | ALDH1A1 (0.52) | HSD17B10KMT2AMAPTMEN1MAPK1 | |
| SCHEMBL2728938 | 0.80 | TDP1 (0.46) | KMT2AMAPTMEN1MAPK1TP53 | |
| SCHEMBL2997140 | 0.80 | ALDH1A1 (0.54) | KMT2AMAPTMEN1TP53CYP3A4 | |
| SCHEMBL2887378 | 0.80 | ALDH1A1 (0.47) | KMT2AMAPTMEN1LMNATP53 | |
| SCHEMBL2887382 | 0.80 | ALDH1A1 (0.47) | KMT2AMAPTMEN1LMNATP53 | |
| SCHEMBL2728943 | 0.80 | TDP1 (0.46) | KMT2AMAPTMEN1MAPK1TP53 | |
| SCHEMBL2997136 | 0.80 | ALDH1A1 (0.54) | KMT2AMAPTMEN1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2112150-B1 | Improved raf inhibitors | FORMA THERAPEUTICS INC (US) | 2013-10-16 | — | — | EP | disclosed |
| US-8232283-B2 | Raf inhibitors | FORMA THERAPEUTICS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110257207-A1 | RAF INHIBITORS | AGENNIX USA INC (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2009130015-A1 | IMPROVED RAF INHIBITORS | GPC BIOTECH AG (DE) | 2009-10-29 | — | — | WO | disclosed |
| EP-2112150-A1 | Improved raf inhibitors | GPC Biotech AG (DE) | 2009-10-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257207-A1 | RAF INHIBITORS | BRAF, RAF1, ARAF | HSD17B10 4250/4885KMT2A 1897/4885PDE7A 1194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.