Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2531890 | 0.83 | CYP11B1 (0.52) | CYP11B1CYP11B2SMN1; SMN2TBXAS1 | |
| SCHEMBL9092962 | 0.78 | CYP11B1 (0.72) | CYP11B1CYP11B2HDAC3MAPK1ADRA1A | |
| SCHEMBL2532821 | 0.76 | CYP11B1 (0.50) | CYP11B1CYP11B2 | |
| SCHEMBL9092547 | 0.75 | CYP11B1 (0.73) | CYP11B1CYP11B2TBXAS1KEAP1 | |
| SCHEMBL6928442 | 0.73 | CYP11B1 (0.56) | CYP11B1CYP11B2MAPK1HDAC6 | |
| SCHEMBL8862697 | 0.72 | CYP11B1 (0.51) | CYP11B1CYP11B2MAPK1HDAC6 | |
| Hydrochloric Acid SCHEMBL25311465 | 0.71 | CYP11B1 (0.38) | CYP11B1CYP11B2HDAC6MAPTPTGS2 | |
| SCHEMBL2789150 | 0.71 | CYP11B1 (0.61) | CYP11B1CYP11B2 | |
| SCHEMBL5324373 | 0.70 | CYP11B1 (0.60) | CYP11B1CYP11B2SMN1; SMN2PTGS2 | |
| SCHEMBL531371 | 0.70 | CYP11B1 (0.73) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382223-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | Novartis AG (CH) | 2011-11-02 | — | — | EP | disclosed |
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2011-10-20 | — | — | US | disclosed |
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2011-10-20 | — | — | US | disclosed |
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2011-10-20 | — | — | US | disclosed |
| WO-2010076258-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | PTEN, INPP5D, PPIP5K2 | CYP11B1 2146/4885CYP11B2 2431/4885HDAC3 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.