Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL25348750 | 1.00 | PRMT1 (0.41) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| SCHEMBL25987253 | 0.92 | PRMT1 (0.40) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| SCHEMBL25986765 | 0.84 | PRMT1 (0.38) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| Bromide SCHEMBL25349033 | 0.81 | PRMT1 (0.47) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| Bromide SCHEMBL30545636 | 0.81 | PRMT1 (0.47) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| SCHEMBL14199091 | 0.73 | MEN1 (0.41) | PRMT1FOLH1MEN1KMT2AMAPT | |
| SCHEMBL21314810 | 0.72 | FOLH1 (0.55) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| SCHEMBL21314811 | 0.72 | FOLH1 (0.55) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| Bromide SCHEMBL25349028 | 0.72 | PRMT1 (0.46) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| Bromide SCHEMBL25349036 | 0.72 | PRMT1 (0.46) | PRMT1PRMT5CARM1PRMT8FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154762-A1 | SQUARAINE FLUOROPHORES | THE GENERAL HOSPITAL CORPORATION (US) | 2023-08-17 | — | — | WO | disclosed |