Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL25349036 | 1.00 | PRMT1 (0.46) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| Bromide SCHEMBL30545636 | 0.91 | PRMT1 (0.47) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| Bromide SCHEMBL25349033 | 0.91 | PRMT1 (0.47) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| Bromide SCHEMBL25348571 | 0.89 | PRMT1 (0.48) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| Bromide SCHEMBL25348580 | 0.89 | PRMT1 (0.48) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| SCHEMBL25986127 | 0.83 | PRMT1 (0.38) | PRMT1PRMT5CARM1PRMT8 | |
| Bromide SCHEMBL30545684 | 0.81 | PRMT1 (0.50) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| Bromide SCHEMBL25348576 | 0.81 | PRMT1 (0.50) | PRMT1PRMT5CARM1PRMT8PTPN1 | |
| SCHEMBL25987253 | 0.80 | PRMT1 (0.40) | PRMT1PRMT5CARM1PRMT8FOLH1 | |
| SCHEMBL18070435 | 0.78 | PRMT1 (0.38) | PRMT1PRMT5CARM1PRMT8PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154762-A1 | SQUARAINE FLUOROPHORES | THE GENERAL HOSPITAL CORPORATION (US) | 2023-08-17 | — | — | WO | disclosed |