Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25356698 | 1.00 | HSD11B1 (0.49) | HSD11B1CYP2D6KMT2AMC4ROPRM1 | |
| SCHEMBL2132365 | 0.79 | CYP2D6 (0.50) | HSD11B1CYP2D6KMT2AMC4RMAPK1 | |
| SCHEMBL4523411 | 0.79 | CYP2D6 (0.50) | HSD11B1CYP2D6KMT2AMC4RMAPK1 | |
| SCHEMBL3285780 | 0.79 | CYP2D6 (0.50) | HSD11B1CYP2D6KMT2AMC4RMAPK1 | |
| SCHEMBL19741641 | 0.78 | CHRM2 (0.49) | HSD11B1CYP2D6KMT2AMC4RMAPK1 | |
| SCHEMBL16070776 | 0.78 | CHRM2 (0.49) | HSD11B1CYP2D6KMT2AMC4RMAPK1 | |
| SCHEMBL10672122 | 0.78 | CHRM2 (0.49) | HSD11B1CYP2D6KMT2AMC4RMAPK1 | |
| SCHEMBL4601165 | 0.75 | CYP2D6 (0.70) | HSD11B1CYP2D6MC4ROPRM1OPRK1 | |
| SCHEMBL19613500 | 0.75 | CYP2D6 (0.70) | HSD11B1CYP2D6MC4ROPRM1OPRK1 | |
| SCHEMBL1586528 | 0.75 | CYP2D6 (0.70) | HSD11B1CYP2D6MC4ROPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |