⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040661 | 0.84 | — | — | |
| SCHEMBL14287476 | 0.79 | — | — | |
| SCHEMBL14040607 | 0.79 | GRIN1 (0.37) | — | |
| SCHEMBL13991089 | 0.74 | — | — | |
| SCHEMBL13990989 | 0.74 | GRIN2D (0.43) | — | |
| SCHEMBL4959783 | 0.69 | GRIN2D (0.38) | — | |
| SCHEMBL7194747 | 0.69 | GAA (0.33) | — | |
| SCHEMBL14287480 | 0.69 | LMNA (0.42) | — | |
| SCHEMBL14287492 | 0.69 | — | — | |
| SCHEMBL14051193 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250129033-A1 | METAP2 INHIBITORS AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2025-04-24 | — | — | US | disclosed |
| EP-4479133-A1 | METAP2 INHIBITORS AND USES THEREOF | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. (IL) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023156996-A1 | METAP2 INHIBITORS AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2023-08-24 | — | — | WO | disclosed |