Leupeptin

Leupeptin

SCHEMBL25361

CC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCNC(=N)N.CCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCNC(=N)N

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 18/20 0.51
NPY1R P25929 11/20 0.51
NPY5R Q15761 10/20 0.51
NPY2R P49146 7/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6674182 0.96 NPY4R (0.54) NPY4RNPY1RNPY5RNPY2R
Leupeptin SCHEMBL13933715 0.94 NPY4R (0.46) NPY4RNPY1RNPY5RNPY2R
Leupeptin SCHEMBL583830 0.94 NPY4R (0.46) NPY4RNPY1RNPY5RNPY2R
Leupeptin SCHEMBL4669504 0.94 NPY4R (0.46) NPY4RNPY1RNPY5RNPY2R
Leupeptin SCHEMBL11021602 0.94 NPY4R (0.46) NPY4RNPY1RNPY5RNPY2R
Leupeptin SCHEMBL11596919 0.93 NPY4R (0.46) NPY4RNPY1RNPY5RNPY2R
SCHEMBL3308386 0.93 NPY4R (0.45) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30643187 0.93 NPY4R (0.45) NPY4RNPY1RNPY5RNPY2R
SCHEMBL16316642 0.89 NPY4R (0.47) NPY4RNPY1RNPY5RNPY2R
SCHEMBL11094153 0.87 SMN1; SMN2 (0.42) NPY4RNPY1RNPY5RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 62603 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122081365-A Alpha-hemolysin recombinant protein and prokaryotic expression method thereof 2026-05-26 CN claimed
CN-122060721-A Nuclear extraction reagent and preparation method and application thereof 北京爱普汇生物科技有限公司 2026-05-19 CN claimed
CN-122012645-A Preparation method of leupeptin and application of leupeptin in agriculture 山东蓬勃生物科技有限公司 2026-05-12 CN claimed
US-20260125640-A1 ACELLULAR PLACENTAL PREPARATIONS PLAKOUS THERAPEUTICS INC (US) 2026-05-07 US claimed
US-12590120-B2 Materials and methods for isolating self-antigen polypeptides Impact Proteomics (US) 2026-03-31 US claimed
US-12584161-B2 Stabilization of nucleic acids in urine STRECK LLC (US) 2026-03-24 US claimed
US-20260014232-A1 Pharmaceutical Composition of GLP-1 and GIP Receptor Dual Agonist and Use Thereof JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN) 2026-01-15 US claimed
EP-4676953-A2 DUAL INHIBITOR KALLIKREIN ANTIBODIES AND USES THEREOF Triveni Bio, Inc. (US) 2026-01-14 EP claimed
EP-4676958-A2 KALLIKREIN ANTIBODIES AND USES THEREOF Triveni Bio, Inc. (US) 2026-01-14 EP claimed
EP-4631514-A1 ORAL POLYPEPTIDE COMPOSITION AND USE THEREOF Hefei Tianhui Biotech Co., Ltd. (CN) 2025-10-15 EP claimed
US-4677069-A Clam derived proteinases CORNELL RESEARCH FOUNDATION, INC. (US) 1987-06-30 US claimed
US-4650763-A Protease and process for production and use thereof SUNTORY LIMITED (JP) 1987-03-17 US claimed
EP-0158981-A2 New protease and process for production and use thereof SUNTORY LIMITED (JP) 1985-10-23 EP claimed
EP-0144993-A2 Promoting animal and plant growth with protease inhibitors GENETIC DIAGNOSTIC CORPORATION (US) 1985-06-19 EP claimed
US-4510130-A Promoting animal and plant growth with leupeptin GENETIC DIAGNOSTICS CORPORATION (US) 1985-04-09 US claimed
EP-0105092-A2 A thrombolytic agent Amano Seiyaku Kabushiki Kaisha (JP) 1984-04-11 EP claimed
US-4434157-A Method of recovering cell antigen and preparation of feline leukemia vaccine therefrom THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1984-02-28 US claimed
EP-0100673-A2 A method of enhancing neurofiber regrowth THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 1984-02-15 EP claimed
US-4284653-A ADDING THIOL PROTEASE INHIBITOR TO PREVENT SOFTENING CAUSED BY SPOROZOA CONTAMINATION NIPPON SUISAN KABUSHIKI KAISHA (JP) 1981-08-18 US claimed
US-4082612-A PLASMINOGEN ACTIVATOR COMPLEX MICHAEL REESE RESEARCH FOUNDATION (US) 1978-04-04 US claimed