Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24113374 | 1.00 | HSD17B10 (0.45) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL7872099 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL13305759 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL8353685 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL7876562 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL5207425 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL1782218 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL5207430 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL1782216 | 0.99 | HSD17B10 (0.44) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL6487183 | 0.94 | HSD17B10 (0.45) | HSD17B10NR1H2SMN1; SMN2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216946-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| CN-116437913-A | Pharmaceutical compounds for treating complement-mediated disorders | 艾其林医药公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022066774-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |