Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 15/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 13/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.46 |
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.45 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30541655 | 0.88 | MAP4K1 (0.41) | ACVR1TGFBR1BMPR1AACVRL1RIPK2 | |
| SCHEMBL25365954 | 0.88 | MAP4K1 (0.41) | ACVR1TGFBR1BMPR1AACVRL1RIPK2 | |
| SCHEMBL30541640 | 0.86 | ACVR1 (0.47) | ACVR1TGFBR1BMPR1AACVRL1MAP4K1 | |
| SCHEMBL25365763 | 0.86 | ACVR1 (0.47) | ACVR1TGFBR1BMPR1AACVRL1MAP4K1 | |
| SCHEMBL25363522 | 0.85 | MAP4K1 (0.39) | MAP4K1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30541654 | 0.85 | MAP4K1 (0.39) | ACVR1TGFBR1MAP4K1 | |
| SCHEMBL25364542 | 0.85 | MAP4K1 (0.39) | ACVR1TGFBR1MAP4K1 | |
| SCHEMBL25365293 | 0.84 | TLR7 (0.45) | MAP4K1KCNH2TLR9TLR8TLR7 | |
| SCHEMBL25365416 | 0.84 | TLR9 (0.42) | ACVR1TGFBR1MAP4K1TLR9TLR8 | |
| SCHEMBL30541587 | 0.84 | TLR9 (0.42) | ACVR1TGFBR1MAP4K1TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159153-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |