Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.63 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2537789 | 0.77 | MAP3K11 (0.66) | PGRMAP3K11 | |
| SCHEMBL5225707 | 0.77 | PGR (1.00) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL719916 | 0.75 | MAP3K11 (1.00) | MAP3K11 | |
| SCHEMBL12886136 | 0.74 | PGR (0.65) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10504098 | 0.74 | MAP3K11 (0.47) | PGRMAP3K11PDE3BPDE3APDE4A | |
| SCHEMBL2270260 | 0.73 | PGR (0.70) | PGRPDE3BPDE3A | |
| SCHEMBL12886131 | 0.73 | PGR (0.63) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10373337 | 0.72 | MAP3K11 (0.45) | PGRMAP3K11 | |
| SCHEMBL10373335 | 0.72 | PDE4A (0.58) | MAP3K11PDE3BPDE3APDE4APDE4B | |
| SCHEMBL3524585 | 0.71 | PGR (0.85) | PGRPDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379561-A2 | MLK INHIBITORS AND METHODS OF USE | University Of Rochester (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |