SCHEMBL25367889

SCHEMBL25367889

Cn1nc(Br)c(C#N)c1NC(=O)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 4/20 0.46
MAPT P10636 1/20 0.46
MTOR P42345 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
ABL1 P00519 10/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
KCNH2 Q12809 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30827449 0.82 MAPT (0.52) TRPV1MAPTMTORHDAC3HDAC4
SCHEMBL30827455 0.82 MAPT (0.52) TRPV1MAPTMTORHDAC3HDAC4
SCHEMBL25366015 0.80 MAPT (0.51) TRPV1MAPTMTORNPC1RAB9A
SCHEMBL14281215 0.73 MEN1 (0.52) TRPV1MAPTNPC1RAB9AABL1
SCHEMBL30827447 0.71 MAPT (0.62) TRPV1MAPTABL1
SCHEMBL30523236 0.71 TRPV1 (0.52) TRPV1MAPTMTORNPC1RAB9A
SCHEMBL30827436 0.70 MAPT (0.44) TRPV1MAPTMTORNPC1RAB9A
SCHEMBL21874355 0.70 MAPT (0.50) TRPV1MAPTNPC1RAB9AHDAC1
SCHEMBL30827442 0.70 MAPT (0.50) TRPV1MAPTMTORNPC1RAB9A
SCHEMBL20520422 0.69 KDR (0.51) TRPV1MAPTNPC1RAB9AHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4590660-A1 AZOLE PESTICIDAL COMPOUNDS BASF SE (DE) 2025-07-30 EP disclosed
US-20250197358-A1 PESTICIDALLY ACTIVE THIOSEMICARBAZONE COMPOUNDS BASF SE (DE) 2025-06-19 US disclosed
CN-119894870-A Azole pesticidal compounds 巴斯夫欧洲公司 2025-04-25 CN disclosed
EP-4479392-A1 PESTICIDALLY ACTIVE THIOSEMICARBAZONE COMPOUNDS BASF SE (DE) 2024-12-25 EP disclosed
CN-118715211-A Pesticidal activity Thiourea compounds 巴斯夫欧洲公司 2024-09-27 CN disclosed
WO-2024061768-A1 AZOLE PESTICIDAL COMPOUNDS BASF SE (DE) 2024-03-28 WO disclosed
WO-2023156402-A1 PESTICIDALLY ACTIVE THIOSEMICARBAZONE COMPOUNDS BASF SE (DE) 2023-08-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250197358-A1 PESTICIDALLY ACTIVE THIOSEMICARBAZONE COMPOUNDS NAT1, TST, CAT TRPV1 760/4885MAPT 241/4885MTOR 1245/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.