Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 7/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536858 | 0.90 | JAK2 (0.40) | JAK2PTK2INSRALK | |
| SCHEMBL521540 | 0.81 | POLB (0.42) | JAK2PTK2TP53PIK3C3MAPT | |
| SCHEMBL2533533 | 0.81 | ALOX5AP (0.39) | JAK2INSRALK | |
| SCHEMBL520694 | 0.81 | POLB (0.38) | JAK2PTK2TP53PIK3C3MAPT | |
| SCHEMBL521225 | 0.79 | POLB (0.36) | JAK2PTK2TP53PIK3C3MAPT | |
| SCHEMBL2530064 | 0.77 | DYRK3 (0.41) | JAK2PTK2INSRALK | |
| SCHEMBL522096 | 0.76 | JAK2 (0.61) | JAK2PTK2INSRALK | |
| SCHEMBL521632 | 0.75 | PIK3C3 (0.47) | JAK2PTK2TP53PIK3C3INSR | |
| SCHEMBL2533530 | 0.73 | ALK (0.38) | JAK2INSRALK | |
| SCHEMBL522726 | 0.73 | INSR (0.44) | JAK2PTK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |