⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25378102 | 0.89 | — | — | |
| SCHEMBL25376451 | 0.81 | — | — | |
| SCHEMBL25377362 | 0.79 | USP2 (0.32) | — | |
| Hydrochloric Acid SCHEMBL25374490 | 0.79 | — | — | |
| SCHEMBL25375866 | 0.76 | — | — | |
| SCHEMBL25375550 | 0.76 | — | — | |
| SCHEMBL1439821 | 0.70 | AOC2 (0.35) | — | |
| SCHEMBL25374413 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL25377623 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL16761535 | 0.68 | AOC2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| US-20230248837-A1 | Technology for Modulating Targeting Chimeras Induced by Cell-Penetrating Peptide and Application Thereof | LIU, MIAO (CN) | 2023-08-10 | — | — | US | disclosed |