Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | FAP | Q12884 | 2/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.51 |
| ▸ | ARG1 | P05089 | 1/20 | 0.46 |
| ▸ | ARG2 | P78540 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31263918 | 1.00 | ROCK2 (0.52) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL25377868 | 0.89 | ROCK2 (0.52) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL8312865 | 0.85 | ROCK2 (0.56) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL4774911 | 0.85 | ROCK2 (0.56) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL4869279 | 0.84 | ROCK2 (0.55) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL8306650 | 0.84 | ROCK2 (0.55) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL25379671 | 0.84 | ROCK2 (0.47) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL17782671 | 0.83 | ROCK2 (0.57) | ROCK2CYP3A4DPP4KMT2AFAP | |
| SCHEMBL23719118 | 0.82 | KMT2A (0.48) | ROCK2CYP3A4KMT2AARG1ARG2 | |
| SCHEMBL23719120 | 0.82 | KMT2A (0.48) | ROCK2CYP3A4KMT2AARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482832-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | Les Laboratoires Servier (FR) | 2025-01-01 | — | — | EP | disclosed |
| WO-2023161317-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2023-08-31 | — | — | WO | disclosed |