Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | KDM4B | O94953 | 1/20 | 0.51 |
| ▸ | KDM5C | P41229 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25376654 | 0.89 | NOS2 (0.59) | KDM4AKDM4BKDM5CKDM5BNOS2 | |
| SCHEMBL29875378 | 0.76 | — | — | |
| SCHEMBL457223 | 0.76 | — | — | |
| Diethylamine SCHEMBL6640415 | 0.74 | UHRF1 (0.41) | NOS2ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL13562418 | 0.73 | NOS2 (0.53) | NOS2KDM1AMAOAMAOBALDH1A1 | |
| SCHEMBL25373541 | 0.73 | KDM5B (0.47) | KDM4AKDM4BKDM5CKDM5BNOS2 | |
| SCHEMBL12845761 | 0.71 | KDM4A (0.57) | KDM4AKDM4BKDM5CKDM5BALDH1A1 | |
| SCHEMBL25299576 | 0.70 | KDM1A (0.44) | NOS2KDM1AMAOAMAOBALDH1A1 | |
| SCHEMBL2259096 | 0.70 | KDM1A (0.47) | KDM4AKDM5CKDM5BNOS2KDM1A | |
| SCHEMBL18160696 | 0.70 | KDM5B (0.45) | KDM4AKDM4BKDM5CKDM5BNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |