Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TYMS | P04818 | 2/20 | 0.47 |
| ▸ | TK1 | P04183 | 1/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25375553 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL25374259 | 0.91 | LMNA (0.55) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL25374258 | 0.91 | LMNA (0.55) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL25374429 | 0.91 | LMNA (0.55) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL25372004 | 0.90 | LMNA (0.56) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL27083620 | 0.90 | LMNA (0.56) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL27149412 | 0.90 | LMNA (0.56) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL25372249 | 0.90 | LMNA (0.56) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL25372007 | 0.90 | LMNA (0.56) | LMNASMN1; SMN2TYMSTK1NT5E | |
| SCHEMBL23474143 | 0.86 | LMNA (0.65) | LMNASMN1; SMN2TYMSTK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043467-A1 | 5'-SUBSTITUTED NUCLEOSIDE MONOPHOSPHATES, PRODRUGS THEREOF, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2024-02-08 | — | — | US | claimed |
| EP-4204428-A1 | 5'-SUBSTITUTED NUCLEOSIDE MONOPHOSPHATES, PRODRUGS THEREOF, AND USES RELATED THERETO | Emory University (US) | 2023-07-05 | — | — | EP | claimed |
| WO-2022047400-A1 | 5'-SUBSTITUTED NUCLEOSIDE MONOPHOSPHATES, PRODRUGS THEREOF, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2022-03-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043467-A1 | 5'-SUBSTITUTED NUCLEOSIDE MONOPHOSPHATES, PRODRUGS THEREOF, AND USES RELATED THERETO | PNP, ENTPD5, TYMP | LMNA 3158/4885SMN1; SMN2 4446/4885TYMS 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.