Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25388925 | 1.00 | HRH3 (0.52) | HRH3NOTUMNPC1RAB9AATM | |
| SCHEMBL25387095 | 0.86 | NOTUM (0.43) | HRH3NOTUMNPC1RAB9AUSP30 | |
| SCHEMBL25391062 | 0.86 | NOTUM (0.43) | HRH3NOTUMNPC1RAB9AUSP30 | |
| SCHEMBL25389887 | 0.86 | NOTUM (0.43) | HRH3NOTUMNPC1RAB9AUSP30 | |
| SCHEMBL25389045 | 0.82 | LIPE (0.47) | HRH3HSD11B1 | |
| SCHEMBL25390100 | 0.82 | LIPE (0.47) | HRH3HSD11B1 | |
| SCHEMBL31288315 | 0.80 | SMN1; SMN2 (0.51) | HRH3NPC1RAB9A | |
| SCHEMBL31288365 | 0.80 | SMN1; SMN2 (0.51) | HRH3NPC1RAB9A | |
| SCHEMBL25391227 | 0.80 | SMN1; SMN2 (0.51) | HRH3NPC1RAB9A | |
| SCHEMBL9791042 | 0.77 | USP30 (0.56) | HRH3NOTUMUSP30SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150186-A1 | DGK TARGETING COMPOUNDS AND USES THEREOF | ARVINAS OPERATIONS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |