Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859719 | 0.91 | — | — | |
| SCHEMBL13554886 | 0.84 | BLM (0.56) | CYP1A2LTA4HBLMGABRR1GPR84 | |
| SCHEMBL148481 | 0.84 | CYP1A2 (0.73) | CYP1A2LTA4HBLMGABRR1FFAR1 | |
| SCHEMBL18317937 | 0.84 | CYP1A2 (0.73) | CYP1A2LTA4HBLMGABRR1FFAR1 | |
| SCHEMBL279916 | 0.84 | CYP1A2 (0.73) | CYP1A2LTA4HBLMGABRR1FFAR1 | |
| SCHEMBL422422 | 0.84 | BLM (0.56) | CYP1A2LTA4HBLMGABRR1GPR84 | |
| Ethylene Glycol SCHEMBL27489872 | 0.83 | CYP1A2 (0.59) | CYP1A2LTA4HBLMGPR84FFAR1 | |
| 1,6-Hexanediol SCHEMBL27541076 | 0.83 | FFAR1 (0.57) | CYP1A2LTA4HBLMCAMK2AGPR84 | |
| SCHEMBL15228384 | 0.83 | LTA4H (0.50) | CYP1A2LTA4HBLMGABRR1GPR84 | |
| SCHEMBL11453210 | 0.82 | CYP1A2 (0.70) | CYP1A2LTA4HBLMGABRR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023171894-A1 | PHARMACEUTICAL COMPOSITION INCLUDING DOCETAXEL OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PREPARATION METHOD THEREFOR | 주식회사 위바이오트리 | 2023-09-14 | — | — | WO | disclosed |
| CN-106459049-A | Tyrosine kinase inhibitors | 普林斯匹亚生物制药公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-101496794-B | Enteric long-acting coating core and medicament dosage form and method for producing the same | HUANENG PHARMACEUTICALS CO LTD | 2013-12-11 | — | — | CN | disclosed |
| CN-102908331-A | Duloxetine hydrochloride enteric capsules and preparation method thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL TECHNOLOGY CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-101496794-A | Enteric long-acting coated core and pharmaceutical dosage form and method for producing the same | TAIWAN BIOTECHNOLOGY CO LTD (CN) | 2009-08-05 | — | — | CN | disclosed |
| CN-100362997-C | Enteric coated table of duloxetine, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2008-01-23 | — | — | CN | disclosed |
| CN-100362996-C | Duloxetine enteric coated tiny pill capsule, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2008-01-23 | — | — | CN | disclosed |
| CN-1759830-A | Enteric coated table of duloxetine, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2006-04-19 | — | — | CN | disclosed |
| CN-1759829-A | Duloxetine enteric coated tiny pill capsule, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2006-04-19 | — | — | CN | disclosed |