Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 1.00 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 1.00 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 1.00 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 1.00 |
| ▸ | MARK3 | P27448 | 17/20 | 0.59 |
| ▸ | SGK1 | O00141 | 3/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.54 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | CSF1R | P07333 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25395801 | 1.00 | ULK1 (1.00) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL25776984 | 0.90 | ULK1 (0.82) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL25776987 | 0.85 | ULK1 (0.74) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL25776990 | 0.84 | ULK1 (0.72) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL25777788 | 0.82 | ULK1 (0.69) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL25776988 | 0.81 | ULK1 (0.69) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL3763029 | 0.78 | ULK1 (0.69) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL3771370 | 0.77 | MARK3 (0.79) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL3763060 | 0.76 | MARK3 (0.66) | ULK1ULK2MKNK2STK17AMARK3 | |
| SCHEMBL3762590 | 0.76 | MARK3 (0.72) | ULK1ULK2MKNK2STK17AMARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293464-A1 | TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA WITH MIRDAMETINIB | SpringWorks Therapeutics Inc. | 2023-09-21 | — | — | US | disclosed |
| WO-2023178276-A1 | TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA WITH MIRDAMETINIB | SpringWorks Therapeutics Inc. (US) | 2023-09-21 | — | — | WO | disclosed |