Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.43 |
| ▸ | EGFR | P00533 | 9/20 | 0.43 |
| ▸ | SRC | P12931 | 5/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.43 |
| ▸ | WEE1 | P30291 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29861345 | 0.82 | WEE1 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL27263923 | 0.82 | WEE1 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL15785449 | 0.82 | FGFR1 (0.44) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL31532094 | 0.81 | FGFR1 (0.56) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL31290940 | 0.78 | FGFR1 (0.57) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL29357943 | 0.78 | WEE1 (0.39) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5061806 | 0.78 | WEE1 (0.39) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL2261009 | 0.78 | FGFR1 (0.57) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL2265749 | 0.77 | WEE1 (0.39) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL29357882 | 0.77 | WEE1 (0.39) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |