Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 3/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31698771 | 1.00 | MAOA (0.44) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL1255123 | 0.82 | KDM4E (0.44) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL25403246 | 0.76 | MAOA (0.48) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL5794104 | 0.73 | MAOA (0.50) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL5226658 | 0.73 | KDM4E (0.53) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL28450343 | 0.73 | KDM4E (0.45) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL9653414 | 0.72 | KDM4E (0.55) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL25405004 | 0.72 | MAOA (0.48) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL1253554 | 0.72 | KDM4E (0.48) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL15675913 | 0.72 | MAOA (0.48) | MAOAKDM4EALDH1A1GLACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164234-A9 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2023164234-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |