Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 11/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.58 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723941 | 0.80 | GRIN1 (0.73) | GRIN1GRIN2BMAP3K11 | |
| SCHEMBL29888611 | 0.73 | GRIN1 (1.00) | GRIN1GRIN2BMAP3K11 | |
| SCHEMBL20134253 | 0.73 | GRIN1 (1.00) | GRIN1GRIN2BMAP3K11 | |
| SCHEMBL11893902 | 0.73 | GRIN1 (0.51) | GRIN1GRIN2BL3MBTL1 | |
| SCHEMBL11893965 | 0.73 | GRIN1 (0.51) | GRIN1GRIN2BL3MBTL1 | |
| SCHEMBL20357946 | 0.72 | MAPK9 (0.54) | GRIN1GRIN2B | |
| SCHEMBL11893888 | 0.71 | GRIN1 (0.52) | GRIN1GRIN2BL3MBTL1 | |
| SCHEMBL11893887 | 0.71 | GRIN1 (0.52) | GRIN1GRIN2BL3MBTL1 | |
| SCHEMBL11221627 | 0.70 | PLD2 (0.43) | GRIN1GRIN2BHTR7 | |
| SCHEMBL20134376 | 0.70 | GRIN1 (1.00) | GRIN1GRIN2BMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379561-A2 | MLK INHIBITORS AND METHODS OF USE | University Of Rochester (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |