Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.69 |
| ▸ | JAK2 | O60674 | 12/20 | 0.69 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25370003 | 0.85 | JAK1 (0.79) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL25370006 | 0.85 | JAK1 (0.79) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL24474853 | 0.85 | JAK1 (0.65) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL25407562 | 0.85 | JAK1 (0.64) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL24474769 | 0.84 | JAK1 (0.66) | JAK1JAK2 | |
| SCHEMBL24474969 | 0.84 | JAK1 (0.68) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL25407580 | 0.84 | JAK1 (0.74) | JAK1JAK2 | |
| SCHEMBL26078109 | 0.83 | JAK1 (0.67) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL25369910 | 0.83 | JAK1 (0.64) | JAK1JAK2JAK3KCNH2 | |
| SCHEMBL25407076 | 0.82 | JAK1 (1.00) | JAK1JAK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353168-B1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2023-08-30 | — | — | EP | disclosed |