Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.58 |
| ▸ | CNR2 | P34972 | 5/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541649 | 1.00 | CNR1 (0.58) | CNR1CNR2CA1CA2CYP19A1 | |
| SCHEMBL2540931 | 1.00 | CNR1 (0.58) | CNR1CNR2CA1CA2CYP19A1 | |
| SCHEMBL2537283 | 0.95 | CNR1 (0.55) | CNR1CNR2CYP19A1MAPTCYP1A2 | |
| SCHEMBL12227216 | 0.94 | CNR1 (0.56) | CNR1CNR2CA1CA2CYP19A1 | |
| SCHEMBL2541779 | 0.93 | CNR1 (0.57) | CNR1CNR2CYP19A1MEN1KMT2A | |
| SCHEMBL2542204 | 0.93 | CNR1 (0.57) | CNR1CNR2CYP19A1MEN1KMT2A | |
| SCHEMBL2537476 | 0.92 | CNR1 (0.54) | CNR1CNR2CA1CA2MAPT | |
| SCHEMBL2538690 | 0.92 | CNR1 (0.52) | CNR1CNR2MAPTCYP3A4GAA | |
| SCHEMBL2536077 | 0.91 | CNR1 (0.50) | CNR1CNR2CYP19A1MAPTALDH1A1 | |
| SCHEMBL12227312 | 0.90 | CNR1 (0.48) | CNR1CNR2MAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044053-B2 | Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2011-10-25 | — | — | US | claimed |
| EP-2079701-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-07-22 | — | — | EP | claimed |
| WO-2008043544-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-04-17 | — | — | WO | claimed |
| US-8044053-B2 | Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2011-10-25 | — | — | US | disclosed |
| US-8044053-B2 | Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2011-10-25 | — | — | US | disclosed |
| US-8044053-B2 | Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2011-10-25 | — | — | US | disclosed |
| US-20100184772-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-07-22 | — | — | US | disclosed |
| US-20100184772-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-07-22 | — | — | US | disclosed |
| US-20100184772-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184772-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | CNR2, CNR1, FAAH | CNR1 2/4885CNR2 1/4885CA1 1741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.