SCHEMBL25413554

SCHEMBL25413554

CN1CCN(C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.54
ATM Q13315 1/20 0.54
HDAC3 O15379 1/20 0.52
ADAM17 P78536 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52
ALDH1A1 P00352 2/20 0.52
LMNA P02545 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
STAT3 P40763 1/20 0.48
GLA P06280 2/20 0.47
MAPK1 P28482 1/20 0.47
EPHX2 P34913 1/20 0.47
DRD2 P14416 1/20 0.47
DRD3 P35462 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30515629 0.89 KMT2A (0.57) KMT2AATMHDAC3ADAM17HDAC1
SCHEMBL25411272 0.88 KMT2A (0.52) KMT2AATMHDAC3ADAM17HDAC1
Hydrochloric Acid SCHEMBL25411024 0.86 HDAC3 (0.52) KMT2AATMHDAC3ADAM17HDAC1
SCHEMBL25411653 0.86 MAPT (0.51) KMT2AATMHDAC3ADAM17HDAC1
SCHEMBL25412639 0.84 ALDH1A1 (0.54) KMT2AATMHDAC3HDAC1HDAC2
SCHEMBL25412118 0.84 KMT2A (0.48) KMT2AATMHDAC3ADAM17HDAC1
SCHEMBL25414135 0.84 KMT2A (0.62) KMT2AATMALDH1A1LMNASMN1; SMN2
SCHEMBL31107132 0.84 KMT2A (0.62) KMT2AATMALDH1A1LMNASMN1; SMN2
SCHEMBL25413408 0.83 HDAC3 (0.46) KMT2AATMHDAC3ADAM17HDAC1
SCHEMBL25409587 0.82 KMT2A (0.47) KMT2AATMHDAC3ADAM17HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023145804-A1 NOVEL B0AT1 INHIBITOR 田辺三菱製薬株式会社 2023-08-03 WO disclosed