Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 16/20 | 0.79 |
| ▸ | CCNC | P24863 | 15/20 | 0.79 |
| ▸ | CDK19 | Q9BWU1 | 5/20 | 0.79 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.72 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.72 |
| ▸ | CDK1 | P06493 | 4/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30369499 | 1.00 | CDK8 (0.79) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL25176626 | 0.90 | CDK8 (0.80) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL30369906 | 0.90 | CDK8 (0.80) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL21750402 | 0.88 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL21750429 | 0.84 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL23780572 | 0.84 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL29472137 | 0.84 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| Hydrochloric Acid SCHEMBL29472145 | 0.83 | CDK8 (0.98) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL21750435 | 0.83 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL29472163 | 0.83 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081452-A1 | SMALL-MOLECULE DEGRADERS OF CDK8 AND CDK19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-05-11 | — | — | WO | disclosed |