Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 15/20 | 1.00 |
| ▸ | CCNC | P24863 | 14/20 | 1.00 |
| ▸ | CDK19 | Q9BWU1 | 5/20 | 1.00 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 1.00 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 1.00 |
| ▸ | CDK1 | P06493 | 6/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21750429 | 1.00 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| Hydrochloric Acid SCHEMBL29472145 | 0.99 | CDK8 (0.98) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL23780572 | 0.93 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL29472163 | 0.91 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL21750435 | 0.91 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL26844095 | 0.90 | CDK8 (0.82) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL23780576 | 0.90 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL21750436 | 0.90 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL23780565 | 0.90 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN | |
| SCHEMBL23780573 | 0.89 | CDK8 (1.00) | CDK8CCNCCDK19MAP4K2HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220098160-A1 | NOVEL CDK 8/19 INHIBITORS | BIOCAD (RU) | 2022-03-31 | — | — | US | claimed |
| US-20240390386-A1 | CDK8/19 INHIBITORS FOR PREVENTING DRUG RESISTANCE | UNIVERSITY OF SOUTH CAROLINA | 2024-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098160-A1 | NOVEL CDK 8/19 INHIBITORS | CDK8, CDK9, CDK18 | CDK8 1/4885CCNC 35/4885CDK19 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.