Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5021496 | 0.82 | PCSK9 (0.59) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL8977438 | 0.78 | NPC1 (0.56) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL22242755 | 0.77 | PCSK9 (0.65) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL1980682 | 0.76 | BCHE (0.58) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL2543034 | 0.74 | NPC1 (0.54) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL1985103 | 0.74 | NPC1 (0.52) | RAB9ANPC1GAASMN1; SMN2TP53 | |
| SCHEMBL4464811 | 0.74 | MEN1 (0.42) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL11451768 | 0.74 | ELANE (0.61) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL4686905 | 0.74 | NPC1 (0.51) | PCSK9RAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL25057028 | 0.73 | NPC1 (0.50) | PCSK9RAB9ANPC1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044078-B2 | Amino-alkyl amide derivatives as CCR3 receptor ligands | SANOFI-AVENTIS (FR) | 2011-10-25 | — | — | US | disclosed |
| US-20080280961-A1 | New amino-alkyl-amide derivatives as CCR3 receptor ligands | SANOFI-AVENTIS (FR) | 2008-11-13 | — | — | US | disclosed |
| EP-1940777-A1 | AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007034253-A1 | AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280961-A1 | New amino-alkyl-amide derivatives as CCR3 receptor ligands | CCR3, CCR1, CCR4 | PCSK9 4117/4885RAB9A 1905/4885NPC1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.