Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30420010 | 1.00 | MET (0.36) | METS1PR1S1PR3GRM5HDAC1 | |
| SCHEMBL25488482 | 0.94 | MET (0.36) | METS1PR1S1PR3GRM5MAPT | |
| SCHEMBL25489376 | 0.89 | MET (0.43) | METGRM5HDAC1MAPTTSHR | |
| SCHEMBL25483821 | 0.84 | MAPT (0.44) | METGRM5HDAC1MAPTTSHR | |
| SCHEMBL25489428 | 0.83 | TSHR (0.40) | METS1PR1GRM5HDAC1TSHR | |
| SCHEMBL31150547 | 0.83 | TSHR (0.40) | METS1PR1GRM5HDAC1TSHR | |
| SCHEMBL25489128 | 0.83 | MET (0.34) | METMAPTTSHRMEN1POLB | |
| SCHEMBL24038686 | 0.81 | MET (0.46) | METHDAC1MEN1POLBKMT2A | |
| SCHEMBL31150561 | 0.78 | MET (0.37) | METGRM5MEN1KMT2ASTAT3 | |
| SCHEMBL25485800 | 0.78 | MET (0.37) | METGRM5MEN1KMT2ASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091606-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091606-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |