Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202038 | 0.90 | CHEK1 (0.48) | MAPTPOLBMEN1KMT2ACHEK1 | |
| SCHEMBL25210030 | 0.90 | CHEK1 (0.53) | MAPTPOLBMEN1KMT2ACHEK1 | |
| SCHEMBL25208410 | 0.90 | MAPT (0.53) | MAPTPOLBMEN1KMT2ACHEK1 | |
| SCHEMBL25225919 | 0.89 | PDE4A (0.58) | MAPTPOLBMEN1KMT2ACHEK1 | |
| SCHEMBL30893737 | 0.87 | CLK4 (0.48) | MAPTPOLBCHEK1NEK2LIMK1 | |
| SCHEMBL30458234 | 0.83 | CHEK1 (0.44) | MAPTPOLBMEN1KMT2ACHEK1 | |
| SCHEMBL25210847 | 0.81 | USP2 (0.47) | MAPTKMT2ACHEK1NEK2LIMK1 | |
| SCHEMBL28110177 | 0.75 | PDE4B (0.57) | POLBMEN1KMT2APDE4BPDE4A | |
| SCHEMBL28014600 | 0.72 | HDAC6 (0.59) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL15815987 | 0.71 | CHEK1 (0.70) | MAPTPOLBMEN1KMT2ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433173-A1 | PYRAZOLE AMIDE BASED COMPOUNDS AND USES AGAINST BREAST CANCER THEREOF | Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) | 2024-09-25 | — | — | EP | disclosed |
| CN-118043310-A | Pyrazole amide-based compounds and their use against breast cancer | 科学与工业研究会(按照印度社会团体注册法案(1860年第21号法案)设立的注册机构) | 2024-05-14 | — | — | CN | disclosed |
| WO-2023089632-A1 | PYRAZOLE AMIDE BASED COMPOUNDS AND USES AGAINST BREAST CANCER THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN. OF SOC. ACT (ACT XXI OF 1860) (IN) | 2023-05-25 | — | — | WO | disclosed |