Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.57 |
| ▸ | PDE4A | P27815 | 4/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28110180 | 0.83 | SMN1; SMN2 (0.48) | PDE4BPDE4APDE4CPDE4DHDAC3 | |
| SCHEMBL28109719 | 0.79 | HDAC3 (0.64) | PDE4BPDE4APDE4CPDE4DHDAC3 | |
| SCHEMBL16934941 | 0.76 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3603088 | 0.76 | NR3C2 (0.53) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL25417232 | 0.75 | MAPT (0.48) | PDE4BPDE4APDE4CPDE4DHDAC3 | |
| SCHEMBL23409921 | 0.74 | PDE4A (0.55) | PDE4BPDE4APDE4CPDE4DHDAC3 | |
| SCHEMBL28109712 | 0.73 | SMN1; SMN2 (0.55) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5584841 | 0.73 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DHDAC3 | |
| SCHEMBL1925453 | 0.73 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DHDAC3 | |
| SCHEMBL1924540 | 0.73 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061975-A | Pyrazolo[1,5-a]pyrimidines as antiviral compounds | 阿波德穆斯公司 | 2016-10-26 | — | — | CN | claimed |
| CN-106061975-B | Pyrazolo [1,5-A] pyrimidine as antiviral compound | 库洛维公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-106061975-A | Pyrazolo[1,5-a]pyrimidines as antiviral compounds | 阿波德穆斯公司 | 2016-10-26 | — | — | CN | disclosed |